DOT Drug Test: What Every Driver Should Know and How It Can Affect Your CDL

If you are a CDL-licensed driver, you should know that the DOT drug test detects five main groups of substances that can immediately take you off the road:

✅ Marijuana (THC)

✅ Cocaine

✅ Amphetamines (Adderall, Vyvanse, Methamphetamine, MDMA, MDA)

✅ Opioids (Codeine, Morphine, Heroin, Hydrocodone, Oxycodone, Oxymorphone, Hydromorphone, Fentanyl, Methadone)

✅ PCP

Any positive result constitutes a violation, is reported to the FMCSA Clearinghouse, and prohibits you from driving until the DOT Return-to-Duty process is completed.

Other substances that may cause a positive result or disqualify you:

• Pain medications: Tramadol, Demerol, Dilaudid

• Anxiety medications: Xanax, Valium, Klonopin (may result in “Unfit” on the DOT physical exam)

• Sleep aids: Ambien, Lunesta

• ADHD medications: Adderall, Vyvanse (high risk if proper medical documentation is missing)

• Weight loss pills: many contain amphetamine derivatives

• CBD products: often contaminated with THC

• Marijuana edibles: gummies, brownies, vapes → even a single gummy can trigger a positive test

• Coca tea and imported herbs: high risk of cocaine-like metabolites

  
  

Even with a prescription, many opioids and stimulants can result in a “Negative with Safety Concern” outcome, which also prohibits driving until formally cleared by the MRO and your physician.

A single pill, gummy, or tea can put your CDL at immediate risk. Always review your medications with your doctor and your employer before taking any substance.

If you test positive, we offer comprehensive assistance with the entire DOT Return-to-Duty process: evaluation, education, follow-up plan, and support until you can legally return to driving.

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